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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SETD2
All Species:
5.76
Human Site:
S425
Identified Species:
21.11
UniProt:
Q9BYW2
Number Species:
6
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BYW2
NP_054878.5
2564
287550
S425
S
Y
S
R
S
E
R
S
H
Y
Y
D
S
D
R
Chimpanzee
Pan troglodytes
XP_516423
2549
285788
D416
R
S
H
Y
Y
D
S
D
R
R
Y
H
R
S
S
Rhesus Macaque
Macaca mulatta
XP_001113652
2550
286209
Y412
S
R
S
E
R
S
H
Y
Y
D
S
D
R
R
Y
Dog
Lupus familis
XP_864158
2562
287091
S421
S
Y
S
R
S
E
R
S
H
Y
Y
D
S
D
R
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418510
2354
262767
A286
S
K
V
E
S
S
H
A
D
V
E
R
R
G
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783359
3042
342758
K470
D
E
E
E
T
K
K
K
S
E
Q
E
E
D
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q2LAE1
1759
193210
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
96.9
92
N.A.
N.A.
N.A.
N.A.
N.A.
61.7
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
24.7
Protein Similarity:
100
98.9
98
94.6
N.A.
N.A.
N.A.
N.A.
N.A.
71.5
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
41.6
P-Site Identity:
100
6.6
20
100
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
13.3
26.6
100
N.A.
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.7
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
15
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
15
0
0
0
0
15
0
15
15
15
0
43
0
43
0
% D
% Glu:
0
15
15
43
0
29
0
0
0
15
15
15
15
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
15
0
% G
% His:
0
0
15
0
0
0
29
0
29
0
0
15
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
15
0
0
0
15
15
15
0
0
0
0
0
0
15
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
15
0
0
0
0
% Q
% Arg:
15
15
0
29
15
0
29
0
15
15
0
15
43
15
29
% R
% Ser:
58
15
43
0
43
29
15
29
15
0
15
0
29
15
15
% S
% Thr:
0
0
0
0
15
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
15
0
0
0
0
0
0
15
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
29
0
15
15
0
0
15
15
29
43
0
0
0
15
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _